Novel Terpenoids from Calocedrus macrolepis var. formosana
β Scribed by Chin-Lin Hsieh; Mei-Hwei Tseng; Ryh-Nan Pan; Jang-Yang Chang; Ching-Chuan Kuo; Tzong-Huei Lee; Yueh-Hsiung Kuo
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 183 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1612-1872
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β¦ Synopsis
Abstract
Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietaneβtype diterpenoids, and 3, with a novel C~20~ο£ΏC~10~ skeleton, is classified as a meroterpenoid. The structures of 1β3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC~50~ value of 9.0Β±0.1β ΞΌM.
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