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Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β1-dependent pathway

✍ Scribed by Jiang, Xiao-Hua; Lam, Shiu-Kum; Lin, Marie CM; Jiang, Shi-Hu; Kung, Hsiang-Fu; Slosberg, Eric D; Soh, Jae Won; Weinstein, I Bernard; Wong, Benjamin Chun-Yu

Book ID
110066935
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
286 KB
Volume
21
Category
Article
ISSN
0950-9232

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Non-steroidal anti-inflammatory drugs (NSAIDs) can induce tumor cells to undergo apoptosis in vitro. They have also shown cancer-preventive activity in vivo. The mechanism of their effects is, however, not well defined. We investigated the mechanism by which a new NSAID, NS398, induces apoptosis in