Key Words Berbmes, oxldatlon, lodme, qumobldme conformatlon Abssbnt 1.2~substituted berbmes, such as (-)-caseamme, (-)-caseadme and (-)-0-methylcaseadme,
Novel Synthesis of the Natural Protoberberine Alkaloids: Oxypalmatine and Oxypseudopalmatine.
β Scribed by Thanh Nguyen Le; Won-Jea Cho
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 22 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Antileukemic benzotclphenanthridine alkaloids, fagaronine (l(Y) and nitidine (1~) were synthesized from the corresponding protoberberines through C6-N bond fission and subsequent cyclization between C6 and Cl3 position of the protoberberines. Fully aromatized 2,3,8,9\_tetraoxygenated benzo[clphenant
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NucleophiLic acylation of 3,44ihydroisoquinoliniinolinium salts 3 with lithiated enol ethers 6, 7, and 8 or vinyl sulfides 14 leads to the adducts 4 9 , and 16, mpctively, in mostly excellent yields. Hydrolysis of 4 alTords 94-97% of the ketones 5, which are transformed by treatment with conc. hydro