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Novel Synthesis of Tetrasubstituted β-Lactones: The Use of Indium in the Electrochemically Supported Reformatsky Reaction

✍ Scribed by Prof. Dr. Hans Schick; Dipl.-Chem. Ralf Ludwig; Dr. Karl-Heinz Schwarz; Chem.-Ing. Katharina Kleiner; Dr. Annamarie Kunath


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
354 KB
Volume
32
Category
Article
ISSN
0044-8249

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Synthesis of tetrasubstituted thiophenes
✍ Georgette M Castanedo; Daniel P Sutherlin 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 107 KB

The Gewald reaction was performed on solid support. This reaction combines a ketone or aldehyde, an activated nitrile, and sulfur in the presence of a suitable amine base to make tri-and tetrasubstituted thiophenes. After optimizing conditions for maximum yield and purity, the scope of the reaction