Synthesis of tetrasubstituted thiophenes
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Georgette M Castanedo; Daniel P Sutherlin
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Article
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2001
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Elsevier Science
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French
⚖ 107 KB
The Gewald reaction was performed on solid support. This reaction combines a ketone or aldehyde, an activated nitrile, and sulfur in the presence of a suitable amine base to make tri-and tetrasubstituted thiophenes. After optimizing conditions for maximum yield and purity, the scope of the reaction