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Novel Synthesis of HPMA Copolymers Containing Peptide Grafts and Their Self-Assembly Into Hybrid Hydrogels

✍ Scribed by Kuangshi Wu; Jiyuan Yang; Čestmír Koňák; Pavla Kopečková; Jindřich Kopeček

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 243 KB
Volume: 209
Category: Article
ISSN: 1022-1352
DOI: 10.1002/macp.200700486

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✦ Synopsis

Abstract

A new pathway for the synthesis of HPMA graft copolymers was developed and their self‐assembly into hybrid hydrogels was investigated. Linear water‐soluble polyHPMA was chosen as the polymer backbone, whereas coiled‐coil forming peptides, covalently attached to the backbone, formed the grafts. Peptides of different chain lengths were chosen for evaluation. The results revealed that graft length greatly affected gelation ability. At least four heptads were needed to facilitate the hybrid system to form hydrogels under the experimental conditions used. The major factors affecting the kinetics of hydrogel self‐assembly were concentration and temperature.

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Hybrid Hydrogels Self-Assembled from HPM

Hybrid Hydrogels Self-Assembled from HPMA Copolymers Containing Peptide Grafts

✍ Jiyuan Yang; Chunyu Xu; Pavla Kopečková; Jindřich Kopeček 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 388 KB

## Abstract **Summary:** Graft copolymers were designed that self‐assemble into hydrogels mediated by the interaction of coiled‐coil peptide domains. A linear hydrophilic polymer of HPMA was chosen as the backbone, and coiled‐coil forming peptides, covalently attached to the backbone, formed the gr