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Novel synthesis of a conformationally-constrained analog of DDATHF

✍ Scribed by Edward C. Taylor; Ping Zhou; Lee D. Jennings; Zhenmin Mao; Baihua Hu; Jong-Gab Jun

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 168 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02397-0

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✦ Synopsis

A conformationally-constrained analog of DDATHF, in which the glutamate moiety is tied back to the benzoyl ring through an isoindolinone ring, has been synthesized through a series of steps which commence with a Diels-Alder reaction of the Danishefsky diene with 4,4-diethoxybut-2-ynal.

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