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Novel synthesis of [13C4,15N]1H-pyrrole-2,3,5-tricarboxylic acid: an important biomarker for melatonin metabolism

✍ Scribed by Marc B. Skaddan

Publisher: John Wiley and Sons
Year: 2009
Tongue: French
Weight: 239 KB
Volume: 53
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1704

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✦ Synopsis

Abstract

1H‐pyrrole‐2,3,5‐tricarboxylic acid is a breakdown product of melatonin. A labeled version of this compound would serve as a key biomarker for drug candidates which track this substance to monitor their effectiveness (e.g. hyperpigmentation drugs). A Hantzsch synthesis using readily available starting materials was used to generate [^13^C~4~,^15^N]1H‐pyrrole‐2,3,5‐tricarboxylic acid in six steps (12% overall yield). Copyright © 2009 John Wiley & Sons, Ltd.

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