Hereditary spastic paraplegia (HSP) describes a heterogeneous group of inherited neurodegenerative disorders in which the cardinal pathological feature is upper motor neurone degeneration leading to progressive spasticity and weakness of the lower limbs. Using samples from a large Omani family we re
β¦ LIBER β¦
Novel syndromic form of X-linked complicated spastic paraplegia
β Scribed by Claes, S. ;Devriendt, K. ;Van Goethem, G. ;Roelen, L. ;Meireleire, J. ;Raeymaekers, P. ;Cassiman, J.J. ;Fryns, J.P.
- Book ID
- 101319250
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 224 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0148-7299
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## Communicated by Mireille Claustres Hereditary spastic paraplegias (HSP) constitute a heterogeneous group of neurodegenerative disorders characterized by slowly progressive spasticity of the lower extremities. Only a few different mutations in the SPG10 gene, KIF5A, have been described in pure d
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