Novel strategic lipase-catalyzed asymmetrization of 1,3-propanediacetate in supercritical carbon dioxide

✍ Scribed by Nobuyuki Mase; Takeshi Sako; Yoshiteru Horikawa; Kunihiko Takabe

• Book ID: 104253921
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 112 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01266-8

✦ Synopsis

In lipase-catalyzed asymmetrization of 1,3-propanediacetate no enantioselectivity was observed in conventional organic solvents, whereas in supercritical carbon dioxide (scCO 2 ) enantioselectivities were observed up to 50% ee, which probably arose from a conformational changing of lipase at the active site due to a transformation of the amino group of lysine into carbamic acid.