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Novel small molecule inhibitors of Bcl-xL anti-apoptotic proteins


Book ID
117659369
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
116 KB
Volume
38
Category
Article
ISSN
0959-8049

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The anti-apoptotic molecules Bcl-xL and
✍ VerΓ³nica AyllΓ³n; Xavier Cayla; Alphonse GarcΓ­a; Aarne Fleischer; Angelita Reboll πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 334 KB

Bcl-xL and Bcl-w specifically interact with PP1alpha and Bad. A phosphatase activity sensitive to okadaic acid was detected in Bcl-xL, Bcl-w and Bad immunoprecipitates. Serine phosphorylation of Bcl-xL and Bcl-w correlates with the number of trimolecular complexes formed. Depletion of Bcl-xL and Bcl