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Novel small molecule activators of the Trk family of receptor tyrosine kinases

✍ Scribed by Obianyo, Obiamaka; Ye, Keqiang

Book ID
121483328
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
190 KB
Volume
1834
Category
Article
ISSN
1570-9639

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Nerve growth factor (NGF) initiates the majority of its biological effects by promoting the dimerization and activation of the tyrosine kinase receptor TrkA. In addition to rapid increases in the phosphorylation of phosphatidylinositol 3Јkinase (PI 3-kinase) and phospholipase C-β₯ and increased ras a