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Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions

✍ Scribed by Takeshi Sakata; Naohiko Anzai; Ho Jung Shin; Rie Noshiro; Taku Hirata; Hirokazu Yokoyama; Yoshikatsu Kanai; Hitoshi Endou

Book ID
116287676
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
176 KB
Volume
313
Category
Article
ISSN
0006-291X

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The organic cation transporter OCTN1 (SLC22A4) is expressed ubiquitously, with strong expression in kidney, trachea, bone marrow, and fetal liver, and it mediates transport of organic cations in a pH-dependent manner. Recent studies have identified single nucleotide polymorphisms (SNPs) of OCTN1 in