Novel silicones for transdermal therapeutic systems: 1. Synthesis of 1-methyl-4-pyridinio-terminated polydimethylsiloxane and evaluation as a transdermal penetration enhancer

Novel silicones for transdermal therapeu

Novel silicones for transdermal therapeutic system, 6. Preparation of oligodimethylsiloxane containing 2-pyrrolidone moiety as a terminal group and its enhancing effect on transdermal drug penetration

✍ Takao Aoyagi; Rie Tadenuma; Yu Nagase 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 509 KB

## Abstract Oligodimethylsiloxanes (ODMSs) containing a 2‐pyrrolidone moiety at one chain end were prepared to develop a silicone‐based transdermal penetration enhancer. The 1‐alkyl‐2‐pyrrolidon‐3‐yl group was introduced as a terminal group of ODMS via the initiator method, i.e., the anionic ring‐o