Novel sesquiterpenes and a lactone from the Jamaican sponge Myrmekioderma styx

✍ Scribed by Jiangnan Peng; Scott G. Franzblau; Fangqiu Zhang; Mark T. Hamann

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 116 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02369-9

✦ Synopsis

Two novel sesquiterpenes, styxone A (1) and styxone B (2), and a novel lactone, styxlactone (3), were isolated from the Jamaican sponge Myrmekioderma styx. Their structures were elucidated by detailed 1 H, 13 C and 2D NMR data and the absolute stereochemistry of styxone A and B was determined by CD spectra. Styxone A represents a novel sesquiterpene skeleton. (S)-(+)-Curcuphenol ( 4), (S)-(+)-curcudiol (5), and abolene (6) were also isolated. An activity enhancement by cyanthiwigin B (7) to curcuphenol was observed in the antimicrobial assays when the two compounds were administered together.