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Novel RNA-binding motif: The KH module

✍ Scribed by S. Adinolfi; C. Bagni; M. A. Castiglione Morelli; F. Fraternali; G. Musco; A. Pastore

Book ID: 102650731
Publisher: Wiley (John Wiley & Sons)
Year: 1999
Tongue: English
Weight: 522 KB
Volume: 51
Category: Article
ISSN: 0006-3525
DOI: 10.1002/(sici)1097-0282(1999)51:2<153::aid-bip5>3.0.co;2-6

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✦ Synopsis

The KH motif has recently been identified in single or multiple copies in a number of RNA associated proteins. Here we review the current knowledge accumulated about the sequence, structure, and functions of the KH. The multidomain architecture of most of the KH-containing proteins inspired an approach based on the production of peptides spanning the sequence of an isolated KH motif. Correct identification of the minimal length necessary for producing a folded peptide has had a number of important consequences for interpreting functional data. The presence of the KH motifs in fmr1, the protein responsible for the fragile X syndrome, and their possible role in the fmr1 functions are also discussed.

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