✦ LIBER ✦
Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization
✍ Scribed by Drazen B. Zimonjic; Catherine L. Keck; Snorri S. Thorgeirsson; Nicholas C. Popescu
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 233 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
To search for recurrent and specific genomic alterations in human hepatocellular carcinoma (HCC), we examined 18 cell lines by comparative genomic hybridization (CGH), a molecular cytogenetic approach that allows positional identification of gains and losses of DNA sequences of the entire tumor genome. We report here a distinct pattern of multiple recurrent DNA copy-number gains and losses that include alterations frequently seen in other neoplasias as well as changes potentially specific for HCC. The most frequent gains were localized on 1p34.