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Novel rearrangements of an N-oxide degradate formed from oxidation of a morpholine acetal substance P antagonist

โœ Scribed by Zhao, Zhongxi Zack (author);Qin, Xue Zhi (author);Wu, Allen (author);Yuan, Yang (author)

Book ID
102400967
Publisher
John Wiley and Sons Inc.
Year
2004
Tongue
English
Weight
88 KB
Volume
93
Category
Article
ISSN
0022-3549

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Novel rearrangements of an N-oxide degra
Novel rearrangements of an N-oxide degradate formed from oxidation of a morpholine acetal substance P antagonist
โœ Zhao, Zhongxi Zack (author);Qin, Xue Zhi (author);Wu, Allen (author);Yuan, Yang ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons Inc. ๐ŸŒ English โš– 88 KB

Compound 1 [5-[2(R)-[1(R)-(3,5-bistrifluoromethylphenyl) ethoxy]-3(s)-(4-fluorophenyl)morpholin-4-ylmethyl]-3h-[1,2,3] triazol-4-ylmethyl]dimethylamine represents a new class of potent, orally active substance P antagonists, which possess a characteristic structural feature-a cis-2-alkoxy-3-arylmorp