Novel rearrangement of 1,2,4-oxadiazoles to 1,2,4-triazolinones
β Scribed by Jones, Stella S.; Staiger, David B.; Chodosh, Daniel F.
- Book ID
- 127297877
- Publisher
- American Chemical Society
- Year
- 1982
- Tongue
- English
- Weight
- 405 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-3263
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The reaction of 3-ethoxycarbonyl-5-perfluoroalkyl-1,2,4-oxadiazoles with hydroxylamines has been investigated, evidencing the possibility of competitive reaction paths. Nucleophilic addition of hydroxylamine to the electrophilic C(5) of the 1,2,4-oxadiazole ring, followed by ring-opening and ring-cl
## Abstract 1,2,4βOxadiazoles and 4,5βdihydroβ1,2,4βoxadiazoles are an interesting class of compounds because of their pharmacological and other properties. Although short descriptions of these compounds under mass spectrometric conditions exist, we thought it worthwhile to write a comprehensive re