Novel quantitative tools for engineering analysis of hepatocyte cultures in bioartificial liver systems

Development of an automated mass spectro

Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

✍ Walter A. Korfmacher; Cynthia A. Palmer; Cymbelene Nardo; Kimberly Dunn-Meynell; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 162 KB 👁 3 views

There is a continuing need for increased throughput in the evaluation of new drug entities in terms of their pharmacokinetic parameters. One useful parameter that can be measured in vitro using liver microsomal preparations is metabolic stability. In this report, we describe an automated system that