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Novel pyrrolo[2,3-d]pyrimidine antifolates: synthesis and antitumor activities

✍ Scribed by Miwa, Tetsuo; Hitaka, Takenori; Akimoto, Hiroshi; Nomura, Hiroaki

Book ID: 121833109
Publisher: American Chemical Society
Year: 1991
Tongue: English
Weight: 833 KB
Volume: 34
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00106a012

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## Abstract Three previously undescribed dihydrofolate reductase (DHFR) inhibitors, N^α^‐[4‐[__N__‐[(2,4‐diaminopyrrolo[2,3‐__d__]pyrimidin‐5‐yl)methyl]amino]benzoyl]‐__N__^δ^‐hemiphthaloyl‐L‐ornithine **(7)**, __N__^α^‐ [4‐ [__N__‐[(2,4‐diaminothieno[2,3‐__d__]pyrimidin‐5‐yl)methyl]amino]benzoyl]‐