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Novel Pyrrole C-Nucleosides by Nitrogen Extrusion from Pyridazine C-Nucleosides.

✍ Scribed by Uday Joshi; Solen Josse; Muriel Pipelier; Floris Chevallier; Jean-Paul Pradere; Roland Hazard; Stephanie Legoupy; Francois Huet; Didier Dubreuil


Publisher
John Wiley and Sons
Year
2004
Weight
114 KB
Volume
35
Category
Article
ISSN
0931-7597

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Synthesis and Some Biochemical Propertie
✍ David Loakes; Danielβ€…M. Brown; Stephenβ€…A. Salisbury; Markβ€…G. McDougall; Constant πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 German βš– 161 KB

## Abstract A novel nucleoside analogue is described based on the pyridazine ring system. The nucleoside was successfully incorporated into DNA __via__ both its phosphoramidite and 5′‐triphosphate derivatives. Enzymatically, the analogue behaves essentially as thymidine: it is a good substrate for