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Novel prodrugs of meropenem with two lipophilic promoieties: synthesis and pharmacokinetics

✍ Scribed by Tanaka, Shunkichi; Matsui, Hiroshi; Kasai, Masayasu; Kunishiro, Kazuyoshi; Kakeya, Nobuharu; Shirahase, Hiroaki

Book ID
109869175
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
621 KB
Volume
64
Category
Article
ISSN
0021-8820

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Novel amides and esters prodrugs of olme
Novel amides and esters prodrugs of olmesartan: Synthesis, bioconversion, and pharmacokinetic evaluation
✍ Jin-Hun Park; Jeong-Soo Chang; Mohammed I. El-Gamal; Won-Kyoung Choi; Woong San πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 560 KB

Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters