Identification of three novel mutations
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Katell Peoc'h; Philippe Manivet; Patrice Beaudry; Françoise Attane; Gérard Besso
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Article
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2000
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John Wiley and Sons
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English
⚖ 49 KB
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Inherited prion diseases are characterized by mutations in the PRNP gene encoding the prion protein (PrP). As the other sporadic or infectious prion disease forms, they are almost all characterized by the accumulation in the brain of an abnormal misfolded form of the patient's PrP. Brain extracts ca