Solid phase synthesis of dihydropyrimidi
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Bruce C. Hamper; Kevin Z. Gan; Thomas J. Owen
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Article
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1999
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Elsevier Science
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French
β 247 KB
Malonic acid resin 1 and the corresponding diester 2 have been used for the preparation of dihydropyrimidinones 6 and pyrinn'dinone carboxylic acids g. Knoevenagel condensation of the unsymmetrical resin bound malonat= diestcr 2 followed by condensatiΒ’= with amidines provides dihydropyrimidin0nΒ’ car