Novel Potent Orally Active Selective VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Structure−Activity Relationships, and Antitumor Activities of N -Phenyl- N ‘-{4-(4-quinolyloxy)phenyl}ureas
✍ Scribed by Kubo, Kazuo; Shimizu, Toshiyuki; Ohyama, Shin-ichi; Murooka, Hideko; Iwai, Akemi; Nakamura, Kazuhide; Hasegawa, Kazumasa; Kobayashi, Yoshiko; Takahashi, Noriko; Takahashi, Kazumi; Kato, Shinichiro; Izawa, Toshio; Isoe, Toshiyuki
- Book ID
- 120933699
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 137 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-2623
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We have identified moderately potent and selective inhibitors ofCSF-1R tyrosine kinase activity, t A preliminary SAR study resulted in the identification of compounds 11 and 20 as the most potent analogues in the series (IC50 = 0.18 jaM). The 3-D-conformation of the 4-(N-alkyl-N-phenyi)-aminoquinazo