Novel Polymeric Vesicles with pH-Induced Deformation Character for Advanced Drug Delivery
✍ Scribed by Cheng Zheng; Xiaping Yao; Liyan Qiu
- Book ID
- 102933925
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 515 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1616-5187
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
pH‐Responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH‐sensitive DPA were successfully synthesized and characterized. The copolymer can self‐assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lipophilic and hydrophilic molecules. The pH‐dependent structure change of vesicles was also observed by DLS and TEM. Dox‐loaded vesicles exhibit a sharp pH‐responsive drug release profile and dramatically enhance the cytotoxicity of Dox against Dox‐resistant MCF‐7/adr cells. These results suggest such vesicles based on pH‐responsive polyphosphazene hold great potential for specific drug therapy.
magnified image