## Abstract Traditional PEGylation strategy of peptide and protein usually results in heterogeneous products with wide molecular weight distribution. MonoβPEGylated consensus interferon (CβIFN) with homogeneous molecular weight was prepared by a novel methoxypolyethylene glycol (mPEG) derivative. 2
β¦ LIBER β¦
Novel polyethylene glycol derivative suitable for the preparation of mono-PEGylated protein
β Scribed by Qiang Yun; Ting Chen; Guifeng Zhang; Jingxiu Bi; Guanghui Ma; Zhiguo Su
- Publisher
- Springer Netherlands
- Year
- 2005
- Tongue
- English
- Weight
- 201 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0141-5492
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We have developed a new class of reagents (2) for the covalent attachment of polyethylene glycol to proteins. These reagents (2) are the monomethoxypolyethylene glycol esters of 4-fluoro-3-nitrobenzoic acid. The reaction of 2 with lysine \(\epsilon\)-amino groups produces a chromophore which can be