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Novel polyaminoacidic copolymers as nonviral gene vectors

✍ Scribed by G. Giammona; G. Cavallaro; G. Pitarresi; E. Pedone

Book ID: 106069806
Publisher: Springer
Year: 2000
Weight: 136 KB
Volume: 278
Category: Article
ISSN: 0340-255X
DOI: 10.1007/s003960050011

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## Abstract ## Background The application of polyethylenimine (PEI) in gene delivery has been severely limited by significant cytotoxicity that results from a nondegradable methylene backbone and high cationic charge density. It is therefore necessary to develop novel biodegradable PEI derivates f