Novel Platinum(II) Complexes with Dipyridyl Containing Chelating Ligands and their Products with the Model Nucleobases 1-Methylthymine and 1-Methyluracil
✍ Scribed by Ina Puscasu; Christian Mock; Michael Rauterkus; Axel Röndigs; Gesche Tallen; Suman Gangopadhyay; Johannes E. A. Wolff; Bernt Krebs
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- German
- Weight
- 169 KB
- Volume
- 627
- Category
- Article
- ISSN
- 0372-7874
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✦ Synopsis
The reactions of [Pt(dpma)(H 2 O) 2 ] 2+ (dpma = 2,2'dipyridylmethylamine) and [Pt(dpk)(H 2 O) 2 ] 2+ (dpk = 2,2'-dipyridylketone) with the model nucleobases 1-methylthymine (1-MeT) and 1-methyluracil (1-MeU) were studied. Reaction products were characterized by 195 Pt NMR spectroscopy and by X-ray structure analysis. The symmetric dpma and dpk diaqua complexes form dinuclear complexes with 1-methylthymine, acting as secondary bridging ligand via its N3 and O4 donor atoms. 6) both show a head-to-head arrangement. Biological tests show a significant in vitro antitumor activity of [Pt(dpk)Cl 2 ] against the human glioma cell line U 87.