Novel Physically Crosslinked Polyurethane-block-Poly(vinyl pyrrolidone) Hydrogel Biomaterials

✍ Scribed by Alpesh Patel; Kibret Mequanint

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 281 KB
• Volume: 7
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200600272

✦ Synopsis

Abstract

Successful tissue repair and regeneration relies on the design of new biomaterials that can mediate cell interaction without inflicting undesirable responses. Novel physically crosslinked polyurethane‐block‐poly(vinyl pyrrolidone) hydrogel biomaterials were synthesized by the macroiniferter controlled radical polymerization method. The structures of the hydrogels were studied by FT‐IR and ^1^H NMR. Hydrogels with EWC up to 37 wt.‐% were prepared. The presence of the PVP block significantly increased the hard‐segment glass transition temperature. Vascular smooth muscle cell attachment and spreading on the hydrogels indicated that these materials have a potential for use as scaffolds in tissue engineering.

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