Novel pH responsive polymethacrylic acid–chitosan–polyethylene glycol nanoparticles for oral peptide delivery

Characterization of pH-responsive hydrog

Characterization of pH-responsive hydrogels of poly(itaconic acid-g-ethylene glycol) prepared by UV-initiated free radical polymerization as biomaterials for oral delivery of bioactive agents

✍ Tania Betancourt; Juan Pardo; Ken Soo; Nicholas A. Peppas 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 506 KB

## Abstract Effective oral delivery of proteins is impeded by steep pH gradients and proteolytic enzymes in the gastrointestinal tract, as well as low absorption of the proteins into the bloodstream because of their size, charge, or solubility. In this work, pH‐responsive complexation hydrogels of