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Novel ortho ester-based, pH-sensitive cationic lipid for gene delivery in vitro and in vivo

✍ Scribed by Guo, Xin; Gagne, Lucie; Chen, Haigang; Szoka, Francis C.

Book ID
121394838
Publisher
Informa plc
Year
2013
Tongue
English
Weight
319 KB
Volume
24
Category
Article
ISSN
0898-2104

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✍ Otmane Boussif; JΓ©rΓ΄me Gaucheron; Caroline Boulanger; Catherine Santaella; Hanno πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 164 KB

## Background: One of the main drawbacks of synthetic, non-viral gene vectors is their relatively low in vivo efficiency when compared with viral vectors. the present paper describes the use of a partially fluorinated glycerophosphoethanolamine (f-pe), a close analog of dope, which, as a helper lip