✦ LIBER ✦

Novel Openers of Ca2+-Dependent Large-Conductance Potassium Channels: Symmetrical Pharmacophore and Electrophysiological Evaluation of Bisphenols

✍ Scribed by Yi Li; Graham Johnson; Jeffrey L Romine; Nicholas A Meanwell; Scott W Martin; Steven I Dworetzky; Christopher G Boissard; Valentin K Gribkoff; John E Starrett Jr

Book ID: 108477451
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 128 KB
Volume: 13
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(03)00156-2

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Novel Openers of Ca2+-Dependent Large-Co

Novel Openers of Ca2+-Dependent Large-Conductance Potassium Channels: Symmetrical Pharmacophore and Electrophysiological Evaluation of Bisphenols.

✍ Yi Li; Graham Johnson; Jeffrey L. Romine; Nicholas A. Meanwell; Scott W. Martin; 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 70 KB

## Abstract For Abstract see ChemInform Abstract in Full Text.

The discovery of novel openers of Ca2+-d

The discovery of novel openers of Ca2+-dependent large-conductance potassium channels: Pharmacophore search and physiological evaluation of flavonoids

✍ Yi Li; John E. Starrett; Nicholas A. Meanwell; Graham Johnson; William E. Harte; 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 229 KB

Three-dimensional database searching based on the pharmacophore model of the known maxi-K opener NS-004 (1) and electrophysiological evaluation led to the discovery of flavonoids (3c and 3d) as openers of the cloned maxi-K channel mSlo expressed in Xeraopus luevis oocytes. The cyclic constrained fla

ChemInform Abstract: The Discovery of No

ChemInform Abstract: The Discovery of Novel Openers of Ca2+-Dependent Large-Conductance Potassium Channels: Pharmacophore Search and Physiological Evaluation of Flavonoids.

✍ Y. LI; J. E. STARRETT; N. A. MEANWELL; G. JOHNSON; W. E. HARTE; S. I. DWORETZKY; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB

The synthesis and structure–activity rel

The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

✍ Piyasena Hewawasam; Wenhong Fan; Jay Knipe; Sandra L Moon; Christopher G Boissar 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 127 KB

The Synthesis and Structure—Activity Rel

The Synthesis and Structure—Activity Relationships of 4-Aryl-3-aminoquinolin-2-ones: A New Class of Calcium-Dependent, Large Conductance, Potassium (Maxi-K) Channel Openers Targeted for Post-Stroke Neuroprotection.

✍ Piyasena Hewawasam; Wenhong Fan; Jay Knipe; Sandra L. Moon; Christopher G. Boiss 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB 👁 2 views

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3 H )-one, BMS-191011: Opener of Large-Conductance Ca 2+ -Activated Potassium (Maxi-K) Channels, Identification, Solubility, and SAR

✍ Romine, Jeffrey L.; Martin, Scott W.; Meanwell, Nicholas A.; Gribkoff, Valentin 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 265 KB