✦ LIBER ✦
Novel N,N-Bidentate Ligands for Enantioselective Copper(I)- Catalyzed Allylic Oxidation of Cyclic Olefins
✍ Scribed by Qitao Tan; Masahiko Hayashi
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 222 KB
- Volume
- 350
- Category
- Article
- ISSN
- 1615-4150
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
New N,N‐bidentate Schiff base ligands containing the 2‐quinolyl moiety proved to be effective in conferring high reactivity and moderate to high enantioselectivity (up to 84% ee) to the copper(I)‐catalyzed asymmetric allylic oxidation of various cylic olefins with tert‐butyl perbenzoate. As copper(I) sources, we employed copper(II) triflate/phenylhydrazine [Cu(OTf)~2~/PhNHNH~2~] and tetra(acetonitrile)copper hexafluorophosphate [Cu(CH~3~CN)~4~PF~6~]. Using the same N,N‐bidentate Schiff base ligand, the former showed high reactivity and the latter showed high enantioselectivity.