Novel ‘Nano in Nano’ Composites for Sustained Drug Delivery: Biodegradable Nanoparticles Encapsulated into Nanofiber Non-Wovens

✍ Scribed by Moritz Beck-Broichsitter; Marcel Thieme; Juliane Nguyen; Thomas Schmehl; Tobias Gessler; Werner Seeger; Seema Agarwal; Andreas Greiner; Thomas Kissel

• Book ID: 102933879
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 978 KB
• Volume: 10
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.201000100

✦ Synopsis

Abstract

Novel ‘nano in nano’ composites consisting of biodegradable polymer nanoparticles incorporated into polymer nanofibers may efficiently modulate drug delivery. This is shown here using a combination of model compound‐loaded biodegradable nanoparticles encapsulated in electrospun fibers. The dye coumarin 6 is used as model compound for a drug in order to simulate drug release from loaded poly(lactide__‐co‐__glycolide) nanoparticles. Dye release from the nanoparticles occurs immediately in aqueous solution. Dye‐loaded nanoparticles which are encapsulated by electrospun polymer nanofibers display a significantly retarded release.
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