Novel mutant mice secreting soluble CD4 without expression of membrane-bound CD4

Constitutive expression of high levels o

Constitutive expression of high levels of soluble mouse CD4 in transgenic mice does not interfere with their immune function

✍ Susanna Weber; André Traunecker; Klaus Karjalainen 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 826 KB

## Abstract Interactions of CD4 with the major histocompatibility complex (MHC) class II molecules are crucial during thymic development and subsequently for the function of single‐positive CD4^+^CD8^−^ T lymphocytes. Here, we have investigated the potential effects of soluble CD4 (sCD4) on the imm