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Novel missense polymorphism in the regulator of G-protein signaling 10 gene: analysis of association with schizophrenia

โœ Scribed by AKITOYO HISHIMOTO; OSAMU SHIRAKAWA; NAOKI NISHIGUCHI; SHINSUKE AOYAMA; HISAE ONO; TAKESHI HASHIMOTO; KIYOSHI MAEDA

Book ID
108961778
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
47 KB
Volume
58
Category
Article
ISSN
1323-1316

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The cholecystokinin A receptor (CCK-AR) modulates CCK-stimulated dopamine release in the posterior nucleus accumbens, and its gene is mapped to 4p15.2-15.1 with the dopamine receptor 5 (DR5) gene. We speculated that alterations in the CCK-AR lead to an increase in dopamine release, which may in turn