Novel methods for analysis of genomic DNA methylation
β Scribed by Frank Lyko
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 140 KB
- Volume
- 381
- Category
- Article
- ISSN
- 1618-2650
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## DNA sequences in complex genomes of Cologne, Koeln, Germany A new protocol, termed methylation-sensitive amplicon subtraction (MS-AS), has been developed for the identification and cloning of aberrantly methylated DNA segments in complex genomes. This method is based on the preparation of ampli
## Abstract Epigenetic alterations of gene function play a central role in the pathogenesis of many tumors and in the process of aging. Abnormal methylation at transcriptional sites of genes results in epigenetic silencing of the genes that protect against tumor formation or that repair DNA. To dat