𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel Method for the Synthesis of Molecularly Imprinted Polymer Bead Libraries

✍ Scribed by Henrik Kempe; Maria Kempe

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
404 KB
Volume
25
Category
Article
ISSN
1022-1336

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Summary: A novel method for the synthesis of spherical molecularly imprinted polymer (MIP) beads by suspension polymerization in mineral oil is described. The usefulness of the method was demonstrated by the synthesis of a propranolol imprinted MIP library. The composition of the library was generated by statistical experimental design. Multivariate data analysis correlated the screening data, obtained by a radioligand binding assay, to the composition of the MIPs.

Light micrograph of MIP beads (MIP 4; size fraction 25–50 ΞΌm).

magnified imageLight micrograph of MIP beads (MIP 4; size fraction 25–50 ΞΌm).

πŸ“œ SIMILAR VOLUMES

Preparation and evaluation of a molecula
Preparation and evaluation of a molecularly imprinted polymer for the selective recognition of testosteroneβ€”application to molecularly imprinted sorbent assays
✍ Bernadette Tse Sum Bui; Karsten Haupt πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 457 KB

Biomimetic testosterone receptors were synthesized via molecular imprinting for use as antibody mimics in immunoassays. As evaluated by radioligand binding assays, imprinted polymers prepared in acetonitrile were very specific for testosterone because the nonimprinted control polymers bound virtuall

Crown ethers as a tool for the preparati
Crown ethers as a tool for the preparation of molecularly imprinted polymers
✍ HΓ₯kan S. Andersson; Olof RamstrΓΆm πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 80 KB πŸ‘ 2 views

Molecularly imprinted polymers have been prepared against aniline and a bis-aniline compound, making use of a crown ether (18-crown-6) to solubilize the monomer-template complexes. Subsequent chromatographic rebinding studies in the absence of crown ether revealed regioselectivity for the templates

Screening of bitterness-suppressing agen
Screening of bitterness-suppressing agents for quinine: The use of molecularly imprinted polymers
✍ Tazuko Ogawa; Kaori Hoshina; Jun Haginaka; Chie Honda; Toshiko Tanimoto; Takahir πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 250 KB πŸ‘ 1 views

The purpose of the present study was to examine the possibility of using molecularly imprinted polymers (MIPs) to screen for bitterness-suppressing agents. Quinine was selected as the bitter substance standard. L-arginine (L-Arg), L-ornithine (L-Orn), L-lysine (L-Lys), and L-citrulline (L-Ctr) were