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Novel Marine Phenazines as Potential Cancer Chemopreventive and Anti-Inflammatory Agents

โœ Scribed by Kondratyuk, Tamara P.; Park, Eun-Jung; Yu, Rui; van Breemen, Richard B.; Asolkar, Ratnakar N.; Murphy, Brian T.; Fenical, William; Pezzuto, John M.

Book ID
120344636
Publisher
MDPI Publishing
Year
2012
Tongue
English
Weight
407 KB
Volume
10
Category
Article
ISSN
1660-3397

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Two new (**1** and **2**) and one known phenazine derivative (lavanducyanin, **3**) were isolated and identified from the fermentation broth of a marine-derived __Streptomyces__ sp. (strain CNS284). In mammalian cell culture studies, compounds **1**, **2** and **3** inhibited TNF-ฮฑ-induced NFฮบB acti

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