Worldwide, the DNA mismatch repair genes MSH2 and MLH1 account for a major share and almost equal proportions of hereditary nonpolyposis colorectal cancer (HNPCC). Furthermore, the predisposing mutation usually varies from kindred to kindred. In this study, we screened 29 verified or putative HNPCC
Novel LOVD databases for hereditary breast cancer and colorectal cancer genes in the Chinese population
β Scribed by Min Pan; Peikuan Cong; Yue Wang; Changsong Lin; Ying Yuan; Jian Dong; Santasree Banerjee; Tao Zhang; Yanling Chen; Ting Zhang; Mingqing Chen; Peter Hu; Shu Zheng; Jin Zhang; Ming Qi
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 288 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1059-7794
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## Abstract Clinical criteria, microsatellite analysis (MSA) and immunohistochemistry (IHC) are important diagnostic tools for identification of hereditary nonpolyposis colorectal cancer (HNPCC) patients who are likely to carry pathogenic germline mutations in mismatch repair genes. Based on MSA an
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