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Novel kinase inhibitors in renal cell carcinoma: Progressive development of static agents

✍ Scribed by Apurva A. Desai; Walter M. Stadler

Book ID
107546375
Publisher
Current Science Inc.
Year
2005
Tongue
English
Weight
258 KB
Volume
7
Category
Article
ISSN
1523-3790

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✍ Brian I. Rini; Vivian Weinberg; Vanessa Shaw; Janet Scott; Robert Bok; John W. P πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 80 KB

## Abstract ## BACKGROUND Renal cell carcinoma (RCC) is characterized by von Hippel‐Lindau gene inactivation and vascular endothelial growth factor (VEGF) overproduction. The mechanism of VEGF overproduction may involve protein kinase C (PKC) delta and zeta isoforms. UCN‐01 (7‐hydroxystaurosporine