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Novel Isocyanide-Based Three-Component Synthesis of 3,4-Dihydroquinoxalin-2-amine Derivatives

✍ Scribed by Maleki, Ali; Mofakham, Hamid; Khavasi, Hamid Reza; Shaabani, Ahmad


Book ID
111954690
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
98 KB
Volume
10
Category
Article
ISSN
1520-4766

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Starting from readily available o-phenylenediamines 1, ketones 2 and isocyanides 3, a variety of highly substituted 3,4-dihydroquinoxalin-2-amine derivatives 4 were efficiently synthesized in the presence of catalytic amount of cerium(IV) ammonium nitrate at room temperature. The flexibility of this

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## Abstract A novel and efficient isocyanide‐based multicomponent reaction between alkyl or aryl isocyanides **1**, 2,3‐diaminomaleonitrile (**2**), naphthalene‐2,3‐diamines (**6**) or benzene‐1,2‐diamine (**9**), and 3‐oxopentanedioic acid (**3**) or __Meldrum__'s acid (**4**) or ketones **7** was