Novel inhibitors of cell adhesion molecule expression

✍ Scribed by Dharmpal S. Dodd; Zhongqi Shen; Takao Nishi; Norma Graber; Dawson Bealls; Miranda Fong; Tracy Ebert

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 352 KB
• Volume: 6
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(96)00504-5

✦ Synopsis

2-Alkylsulfinyl-l,3,4-oxadiazoles have been identified as novel inhibitors of cell adhesion molecule expression on endothelial cells. These compounds have been shown to inhibit the up-regulation of ELAM-1 and VCAM-1 on activated human umbilical vein endothelial cells (HUVECs) as measured by ELISA.