## Abstract __N__β²β(11Hβindolo[3,2βc]quinolinβ6βyl)β__N__,__N__βdimethylethaneβ1,2βdiamine (IQDMA), an indoloquinoline derivative, synthesized in our laboratory, has been demonstrated to be an effective antitumor agent in human leukemia cells. In the present study, treatment with IQDMA inhibited ph
Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells
β Scribed by Ching-Ming Chien; Sheng-Huei Yang; Kuei-Li Lin; Yeh-Long Chen; Long-Sen Chang; Shinne-Ren Lin
- Book ID
- 113517749
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 730 KB
- Volume
- 176
- Category
- Article
- ISSN
- 0009-2797
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N'-(11H-Indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (IQDMA), an indoloquinoline derivative, synthesized in our laboratory, has been demonstrated to be an effective anti-tumor agent in human leukemia cells. Treatment of K562 cells with IQDMA resulted in G2/M phase cell cycle arrest, pr
Background: KRN5500, a derivative of spicamycin, shows antitumor activity against a variety of tumor cell lines. However, the mechanism of cytotoxic action has remained unclear. Methods: The viability of HL-60 human leukemic cells treated with KRN5500 was studied by the dye exclusion assay. Inductio