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Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells

✍ Scribed by Ching-Ming Chien; Sheng-Huei Yang; Kuei-Li Lin; Yeh-Long Chen; Long-Sen Chang; Shinne-Ren Lin


Book ID
113517749
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
730 KB
Volume
176
Category
Article
ISSN
0009-2797

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## Abstract __N__′‐(11H‐indolo[3,2‐c]quinolin‐6‐yl)‐__N__,__N__‐dimethylethane‐1,2‐diamine (IQDMA), an indoloquinoline derivative, synthesized in our laboratory, has been demonstrated to be an effective antitumor agent in human leukemia cells. In the present study, treatment with IQDMA inhibited ph

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N'-(11H-Indolo[3,2-c]quinolin-6-yl)-N,N-dimethylethane-1,2-diamine (IQDMA), an indoloquinoline derivative, synthesized in our laboratory, has been demonstrated to be an effective anti-tumor agent in human leukemia cells. Treatment of K562 cells with IQDMA resulted in G2/M phase cell cycle arrest, pr

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