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Novel indolactam-based inhibitors of matrix metalloproteinases

โœ Scribed by Arlindo L. Castelhano; Roland Billedeau; Nolan Dewdney; Sheila Donnelly; Stephen Horne; Lilia J. Kurz; T.J. Liak; Robert Martin; Rhonda Uppington; Zhengyu Yuan; Allen Krantz

Book ID
108038854
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
343 KB
Volume
5
Category
Article
ISSN
0960-894X

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Phosphinic acid inhibitors of matrix met
Phosphinic acid inhibitors of matrix metalloproteinases
โœ Charles G. Caldwell; Soumya P. Sahoo; Scott A. Polo; Randall R. Eversole; Thomas ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 322 KB

The matrix metalloproteinase stromelysin-1 (MMP-3) is inhibited more strongly by peptidyl phosphinic acid 7 than by its corresponding phosphonamidate and phosphonate analogs. Extending a benzyl group at PI' to a phenylethyl group in 8 further increases the potency (Ki = 1.4 nM). Enhanced potency wit