Novel Hydroxyicosatetraenoic and Hydroxyicosapentaenoic Acids and a 13-Oxo Analog. Isolation from a Mixture of the Calcareous Red Algae Lithothamnion corallioides and Lithothamnion calcareum of Brittany Waters
✍ Scribed by Antonio Guerriero; Michele D'Ambrosio; Francesco Pietra
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- German
- Weight
- 444 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A mixture of the red calcareous algae Lithothamnion corallioides CROUAN and Lithothamnion calcareum (PALLAS) ARESCHOUGH, from Brittany waters, gives, on ethanolic extraction, the novel icosanoids ethyl 13‐hydroxy‐arachidonate (=(+)‐all‐Z‐ethyl 13‐hydroxyicosa‐5,8, 11,14,‐tetraenoate; (+)‐1)), ethyl 13‐hydroxytimnodonate (=(+)‐(all‐Z)‐ethyl 13‐hydroxyicosa‐5,8,11,14,17‐pentaenoate ((+)‐2), and (5__Z__,9__E__,11__E__,14__E__)‐ethyl 8‐hydroxy‐13‐oxoicosa‐5,9,11,14‐tetraenoate (3). Moreover, the ethyl esters of four known icosatetraenoic acids are contained in the above algae. Structural elucidations of these metabolites are based mainly on NMR data.