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Novel graft copolymers enhance in vitro delivery of antisense oligonucleotides in the presence of serum

✍ Scribed by Lavanya Y. Peddada; Nicole K. Harris; David I. Devore; Charles M. Roth


Book ID
113693046
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
346 KB
Volume
140
Category
Article
ISSN
0168-3659

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## Abstract In the current study, we evaluated the efficiency of folate‐polyamidoamine dendrimers conjugates (FA‐PAMAM) for the __in situ__ delivery of therapeutic antisense oligonucleotides (ASODN) that could inhibit the growth of C6 glioma cells. Folic acid was coupled to the surface amino groups