Novel Functional Hyperbranched Polyether Polyols as Prospective Drug Delivery Systems

✍ Scribed by Leto-Aikaterini Tziveleka; Christina Kontoyianni; Zili Sideratou; Dimitris Tsiourvas; Constantinos M. Paleos

• Book ID: 102469886
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 203 KB
• Volume: 6
• Category: Article
• ISSN: 1616-5187
• DOI: 10.1002/mabi.200500181

✦ Synopsis

Abstract

Summary: Multifunctional hyperbranched polyether polyols bearing protective poly(ethylene glycol) (PEG) chains with or without the folate targeting ligand at their end have been prepared. Solubilization in these polymers of a fluorescent probe, pyrene, and an anticancer drug, tamoxifen, was physicochemically investigated. It was found that PEG chains attached at the surface of these hyperbranched polymers, in addition to their well‐established protective role, enhance the encapsulation efficiency of the polymers. The release of pyrene and tamoxifen observed upon addition of sodium chloride is, in most of the cases, significant only at concentrations exceeding the physiological extracellular concentration. Thus, a significant amount of the probe or drug remains solubilized inside the carriers, which is an encouraging result if the polymers are to be used for drug delivery.

Schematic representation of the multifunctional hyperbranched polyether polyol bearing protective poly(ethylene glycol) (PEG) chains with folate targeting ligand.

magnified imageSchematic representation of the multifunctional hyperbranched polyether polyol bearing protective poly(ethylene glycol) (PEG) chains with folate targeting ligand.