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Novel Function of Transcription Factor ATF5: Blockade of p53-dependent Apoptosis Induced by Irradiation

โœ Scribed by T. Nishioka; M. Yasuda; H. Haga; R. Yamazaki; K. Tsutsumi; H. Shirato


Book ID
108148614
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
39 KB
Volume
72
Category
Article
ISSN
0360-3016

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Mice generated by homologous recombination which carry a large deletion of the p53 tumour suppressor gene have a high incidence of spontaneous Thy1-positive thymic lymphoma. Extra-thymic lymphomas are rare. Apoptosis following -irradiation in thymocytes from these animals in vitro is p53-dependent a